Ultrasonography showed that 82.4% of normal weight males received intramuscular injections all overweight and obese females received subcutaneous injections. Assessments included depot depth (ultrasonography), plasma adrenaline levels (liquid chromatography‐tandem mass spectrometry) and heart rate (HR ECG Holter monitor). ![]() In this exploratory open‐label, single‐centre study, 54 healthy volunteers aged 18‐50 years received a single 500 μg adrenaline injection (Anapen auto‐injector) in the thigh (antero‐lateral middle third or antero‐inferior third ). This study evaluated the pharmacokinetics (PK) and pharmacodynamic (PD) CV profiles after a single 500 μg adrenaline injection via Anapen auto‐injector in healthy normal weight males and otherwise healthy, overweight or obese females. However, overweight/obese patients may require a higher adrenaline dose for adequate cardiovascular (CV) response. ![]() ![]() ![]() Anaphylaxis guidelines recommend intramuscular adrenaline, commonly 300 μg administered using an auto‐injector device.
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